January 31 | Webinar: Leveraging Single-Cell Genomics to Identify Drivers of Enhanced Immunity
Immune homeostasis requires constant regulation in order to maintain the balance between a diverse and dynamic set of cell types under normal physiological conditions. Within immune tissues, distinct cellular subsets must work together to defend against pathogenic threats, maintain tolerance, and establish memory to restore homeostasis. While surveying multiple healthy individuals enables the exploration of potential ensemble immune solutions, comparing this data against outliers of health and disease can reveal deviations that underscore diagnostic, therapeutic, and prophylactic features of enhanced function or dysfunction.
In this webinar, Alex K. Shalek of the Massachusetts Institute of Technology (MIT) will discuss his work using single-cell genomic approaches — in particular, single-cell RNA-seq — to explore the functional diversity among immune cells within and across individuals. This project aims to uncover distinct cell types and states associated with improved immunity from the molecular level.
Dr. Shalek will also expand on the emerging experimental and computational strategies for altering ensemble cellular responses through targeted intra- or extracellular induction of preferred cell types and states.
Date: Thursday, January 31, 2019
Time: 7:00 pm Europe Time (Paris, GMT+01:00)
1:00 pm Eastern Standard Time (New York, GMT-05:00)
10:00 am Pacific Standard Time (San Francisco, GMT-08:00)
Duration: 1 hour
Registration is required to join this event. If you have not registered, please do so here.
About the speaker:
Alex K. Shalek
Pfizer-Laubach Career Development Assistant Professor
Massachusetts Institute of Technology
Alex K. Shalek’s research is directed towards the development and application of new technologies that facilitate understanding of how cells collectively perform systems-level functions in healthy and diseased states. To date, his interdisciplinary research has focused on realizing and utilizing nanoscale manipulation and measurement technologies to examine how small components (molecules, cells) drive systems of vast complexity (cellular responses, population behaviors).
Dr. Shalek received his bachelor’s degree summa cum laude from Columbia University and his PhD from Harvard University in Chemical Physics under the guidance of Hongkun Park, later performing postdoctoral training under Hongkun Park and Aviv Regev (Broad/MIT). He is currently the Pfizer-Laubach Career Development Assistant Professor at the Massachusetts Institute of Technology (MIT), as well as a core member of the Institute for Medical Engineering and Science (IMES), an Assistant Professor of Chemistry, and an extramural member of the Koch Institute for Integrative Cancer Research. He is also an associate member of the Ragon and Broad Institutes, an assistant in Immunology at Massachusetts General Hospital, and an instructor in Health Sciences and Technology at Harvard Medical School.